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Yemelyan Rybakov
Yemelyan Rybakov

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Filmora 11 has come a really long way in recent years and is now high on our list of best video editing software, especially if you are an absolute beginner. It is available for both Windows and macOS with the free version, and you can download it by using the link above.


If you are looking for the built-in free video editing software for Windows 10/11, the good news is that you can try Microsoft Windows 10/11 Photos app, which is pre-built on your Windows 10 computer, so you don't need to download it again. If you can't find the Photos app, you can install it again from Microsoft Store directly.


The function of a non-protein-coding RNA is often determined by its structure. Since experimental determination of RNA structure is time-consuming and expensive, its computational prediction is of great interest, and efficient solutions based on thermodynamic parameters are known. Frequently, however, the predicted minimum free energy structures are not the native ones, leading to the necessity of generating suboptimal solutions. While this can be accomplished by a number of programs, the user is often confronted with large outputs of similar structures, although he or she is interested in structures with more fundamental differences, or, in other words, with different abstract shapes. Here, we formalize the concept of abstract shapes and introduce their efficient computation. Each shape of an RNA molecule comprises a class of similar structures and has a representative structure of minimal free energy within the class. Shape analysis is implemented in the program RNAshapes. We applied RNAshapes to the prediction of optimal and suboptimal abstract shapes of several RNAs. For a given energy range, the number of shapes is considerably smaller than the number of structures, and in all cases, the native structures were among the top shape representatives. This demonstrates that the researcher can quickly focus on the structures of interest, without processing up to thousands of near-optimal solutions. We complement this study with a large-scale analysis of the growth behaviour of structure and shape spaces. RNAshapes is available for download and as an online version on the Bielefeld Bioinformatics Server. 350c69d7ab


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